Retatrutide

Investigational Triple Hormone Receptor Agonist ("Triple-G")

Concentration: 5mg Purity: ≥99% (HPLC Certified) Testing: Verified by HPLC-UV-MS in the USA 🇺🇸

Product Overview

Retatrutide (LY3437943) is a cutting-edge synthetic peptide that represents the next frontier in metabolic research. Known as a "Triple-G" agonist, it is designed to simultaneously activate three distinct receptor pathways: GLP-1(glucagon-like peptide-1), GIP (glucose-dependent insulinotropic polypeptide), and Glucagon.

This investigational compound is currently the subject of the rigorous Phase 3 TRIUMPH program. It is supplied as a high-purity lyophilized powder, strictly intended for in vitro and analytical laboratory use to study complex metabolic interactions and receptor efficacy.

Research Applications

Retatrutide is at the forefront of metabolic science, with key areas of investigation including:

• Triple-Pathway Activation: Studying the synergistic effects of activating GLP-1, GIP, and Glucagon receptors simultaneously.

• Obesity & Weight Management: Benchmarking efficacy in weight loss models; recent research (TRIUMPH-4 readout, Dec 2025) has observed up to ~28.7% mean weight loss in specific trial parameters.

• Comorbidity Research: Investigating effects on conditions associated with excess weight, such as Type 2 diabetes, knee osteoarthritis pain, sleep apnea, and cardiovascular outcomes.

• Metabolic Efficiency: Exploring how triple agonism influences energy expenditure and glucose homeostasis.

Product Specifications

• Active Content: 5mg per vial

• Molecular formula (as labeled): C₂₂₁H₃₄₂N₄₆O₆₈

   

   

• Format: Lyophilized White Powder

• Classification: Investigational Triple Agonist

• Solubility: Refer to Certificate of Analysis (COA) for specific solvent compatibility.

Handling & Storage

• General Handling: Work aseptically. Prepare solutions and store material according to institutional biosafety rules and the specific COA.

• Preservation: Aliquot reconstituted solutions to avoid repeated freeze-thaw cycles, which can degrade the peptide structure.

• Protection: Protect from heat and light exposure when applicable.

• Storage (Powder): Store at -20°C prior to use.

• Storage (Liquid): Follow specific stability guidelines provided in laboratory safety data sheets (SDS).

⚠️ COMPLIANCE & DISCLAIMER

FOR RESEARCH USE ONLY. This product is strictly intended for in vitro laboratory research purposes.

• NOT FDA-Approved: This is an investigational compound.

• NOT for human consumption.

• NOT for veterinary use.

• NO therapeutic claims are made.

By purchasing, the buyer acknowledges they are a qualified researcher and agrees to use this product in compliance with all local, state, and federal laws.